Summary. India has a rich tradition of plants based knowledge on health care. A large number of plants are used by folklore traditional in India for treatment of skin disease, fever, asthma, piles, ourn and wound. Nyctanthes arbortristis linn.(Oleaceae ) is a shrub plant it is used for various type of skin disease. The present study was aimed to evaluate its scientific validity. The alcoholic extract and the hydro gel of same were investigated for the evaluation of its healing efficiency on excision wound model in rats. A different formulation of alcoholic extract was topically applied on the excision wound surface as a single dose. Wound area and histopharmacology were used to evaluate the effect on wound healing. The effect produced by gel in terms of wound contracting ability, wound closure, decrease in surface area of wound. Tissue regeneration at the wound site and histopharmacological characteristics were significant (p<0.01) in treated rats. The present study thus provides a scientific rationale for the traditional use of this plant in the management of the wound. Industrial relevance:-Nyctanthes arbortristis is used for the treatment of skin disease and as a antiseptic for wound .It has been used in folk medicine for the treatment of asthma, piles, fever. In traditional systems there was only claim for the wound healing activity of this plant. How ever, there is no scientific data to support the wound healing activity of Nyctanthes arbortristis crude extract as well as its gel formulation againt the specific micro organism which generally infect wound. The gel is an topical dosage from and easy to formulate. It wound be an economical option for treatment of wounds.
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